Name: Human KRT18 protein (Recombinant) (N-His) (STJP003735)
SKU: STJP003735
Availability: InStock

Human KRT18 protein (Recombinant) (N-His) (STJP003735)

SKU:

STJP003735

£208.50 - £1,163.50

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Short Description :	Recombinant-Human KRT18-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:	ELISA/Immunogen/SDS-PAGE/WB
Host:	E.coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Dilution Range:	Reconstitute in sterile water for a stock solution.
Formulation:	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Post Translational Modifications	Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6. Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7. O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.
Function	Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Protein Name	Keratin - Type I Cytoskeletal 18 Cell Proliferation-Inducing Gene 46 Protein Cytokeratin-18 Ck-18 Keratin-18 K18
Database Links	Reactome: R-HSA-6805567 Reactome: R-HSA-6809371
Cellular Localisation	Nucleus Matrix Cytoplasm Perinuclear Region Nucleus Nucleolus
Alternative Protein Names	Keratin - Type I Cytoskeletal 18 protein Cell Proliferation-Inducing Gene 46 Protein protein Cytokeratin-18 protein Ck-18 protein Keratin-18 protein K18 protein KRT18 protein CYK18 protein PIG46 protein

Information sourced from Uniprot.org

Model	Name	Host	Application
STJP005172	Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172)	E.coli	SDS-PAGE/WB/ELISA/Immunogen
STJP004723	Human WAS protein (Recombinant) (N-His) (STJP004723)	E.coli	ELISA/Immunogen/SDS-PAGE/WB
STJP003416	Human CCNB2 protein (Recombinant) (N-His) (STJP003416)	E.coli	ELISA/Immunogen/SDS-PAGE/WB
STJP003432	Human SGPL1 protein (Recombinant) (N-His) (STJP003432)	E.coli	ELISA/Immunogen/SDS-PAGE/WB
STJP003434	Human H6PD protein (Recombinant) (N-His) (STJP003434)	E.coli	ELISA/Immunogen/SDS-PAGE/WB

Human KRT18 protein (Recombinant) (N-His) (STJP003735)

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