Human KLF4 protein (Recombinant) (N-His) (STJP003272)

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STJP003272
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human KLF4-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: KLF4
Gene ID: 9314
Uniprot ID: KLF4_HUMAN
Immunogen Region: Leu352-Phe513
Immunogen: Homo sapiens (Human)
Function Transcription factor.can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
Protein Name Krueppel-Like Factor 4
Epithelial Zinc Finger Protein Ezf
Gut-Enriched Krueppel-Like Factor
Database Links Reactome: R-HSA-381340
Reactome: R-HSA-422085
Reactome: R-HSA-452723
Reactome: R-HSA-9617828
Cellular Localisation Nucleus
Cytoplasm
Alternative Protein Names Krueppel-Like Factor 4 protein
Epithelial Zinc Finger Protein Ezf protein
Gut-Enriched Krueppel-Like Factor protein
KLF4 protein
EZF protein
GKLF protein

Information sourced from Uniprot.org

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