Human Josephin 1/JOSD1 protein (Recombinant) (His-Tag) (STJP017864)

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STJP017864
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Josephin 1/JOSD1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 40% Glycerol, 5mM DTT, 2mM EDTA
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: JOSD1
Gene ID: 9929
Uniprot ID: JOS1_HUMAN
Immunogen Region: 1-202aa
Accession Number: NP_055691
Immunogen: Human
Immunogen Sequence: MSCVPWK GDKAKSESLE LPQAAPPQIY HEKQRRELCA LHALNNVFQD SNAFTRDTLQ EIFQRLSPNT MVTPHKKSML GNGNYDVNVI MAALQTKGYE AVWWDKRRDV GVIALTNVMG FIMNLPSSLC WGPLKLPLKR QHWICVREVG GAYYNLDSKL KMPEWIGGES ELRKFLKHHL RGKNCELLLV VPEEVEAHQS WRTDV
Post Translational Modifications Monoubiquitinated. Ubiquitination activates deubiquitination activity in vitro.
Function Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity.
Protein Name Josephin-1
Josephin Domain-Containing Protein 1
Database Links Reactome: R-HSA-5689877
Cellular Localisation Cell Membrane
Cytoplasm
Ubiquitination Increases Localization The Plasma Membrane
In The Cytosol
The Unubiquitinated Form May Be Associated With The Cytoskeleton Via Actb-Binding
Alternative Protein Names Josephin-1 protein
Josephin Domain-Containing Protein 1 protein
JOSD1 protein
JSPH1 protein
KIAA0063 protein

Information sourced from Uniprot.org

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