| Function | Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. |
| Protein Name | Junctional Adhesion Molecule-LikeAdhesion Molecule Interacting With Cxadr Antigen 1Dendritic Cell-Specific Protein Crea7-1 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionLocalized At The Plasma Membrane And Enriched In Areas Of Cell-Cell Contacts |
| Alternative Protein Names | Junctional Adhesion Molecule-Like proteinAdhesion Molecule Interacting With Cxadr Antigen 1 proteinDendritic Cell-Specific Protein Crea7-1 proteinJAML proteinAMICA1 proteinUNQ722 proteinPRO1387 protein |
Information sourced from Uniprot.org
