Human JAML protein (Recombinant-Active) (C-His) (STJP012184)

Name: Human JAML protein (Recombinant-Active) (C-His) (STJP012184)
SKU: STJP012184-100
Price: 503.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostMammalian Cells

ConjugationUnconjugated

ImmunogenHomo sapiens (Human)

STJP012184-100

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Short Description	Recombinant-Active-Human JAML-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	<0.1 EU/Mu g of the protein by the LAL method.
Immunoreactivity	Measured by the ability of the Immobilised protein to support the adhesion of human breast cancer cells (BT‑20). When 5 x 10^4 cells/well are added to rhJAML coated plates (10 µg/mL, 100 µL/well) , approximately 55%-75% will adhere after 1 hour at 37

Function	Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
Protein Name	Junctional Adhesion Molecule-Like Adhesion Molecule Interacting With Cxadr Antigen 1 Dendritic Cell-Specific Protein Crea7-1
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-202733
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Cell Junction Localized At The Plasma Membrane And Enriched In Areas Of Cell-Cell Contacts
Alternative Protein Names	Junctional Adhesion Molecule-Like protein Adhesion Molecule Interacting With Cxadr Antigen 1 protein Dendritic Cell-Specific Protein Crea7-1 protein JAML protein AMICA1 protein UNQ722 protein PRO1387 protein

Information sourced from Uniprot.org