Human JADE1 protein (Recombinant) (N-His) (STJP009654)

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STJP009654
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human JADE1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: JADE1
Gene ID: 79960
Uniprot ID: JADE1_HUMAN
Immunogen Region: Gly217-Ser363
Immunogen: Homo sapiens (Human)
Function Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation. May also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling.at least in part, cooperates with NPHP4 in this function.
Protein Name Protein Jade-1
Jade Family Phd Finger Protein 1
Phd Finger Protein 17
Database Links Reactome: R-HSA-3214847
Cellular Localisation Nucleus
Chromosome
Cytoplasm
Cytoskeleton
Cilium Basal Body
Localizes To The Ciliary Transition Zone
Alternative Protein Names Protein Jade-1 protein
Jade Family Phd Finger Protein 1 protein
Phd Finger Protein 17 protein
JADE1 protein
KIAA1807 protein
PHF17 protein

Information sourced from Uniprot.org

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