Human Isocitrate Dehydrogenase 1/IDH1 protein (Recombinant) (His-Tag) (STJP017408)

SKU:
STJP017408
£134.50 - £738.50
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: E.coli
Applications: SDS-PAGE/Enzyme Activity
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Isocitrate Dehydrogenase 1/IDH1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 1mM DTT, 0.1mM PMSF
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Specific activity is > 18, 000pmol/min/ug. One unit will oxidize 1.0pmole of DL-Isocitrate to D alpha-Ketoglutarate per minute in the presence of beta-NADP at pH7.4 at 37C.
Gene Symbol: IDH1
Gene ID: 3417
Uniprot ID: IDHC_HUMAN
Immunogen Region: 1-414aa
Accession Number: NP_005887.2
Immunogen: Human
Immunogen Sequence: MSKKISGGSV VEMQGDEMTR IIWELIKEKL IFPYVELDLH SYDLGIENRD ATNDQVTKDA AEAIKKHNVG VKCATITPDE KRVEEFKLKQ MWKSPNGTIR NILGGTVFRE AIICKNIPRL VSGWVKPIII GRHAYGDQYR ATDFVVPGPG KVEITYTPSD GTQKVTYLVH NFEEGGGVAM GMYNQDKSIE DFAHSSFQMA LSKGWP
Post Translational Modifications Acetylation at Lys-374 dramatically reduces catalytic activity.
Function Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase. Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways. May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency.
Protein Name Isocitrate Dehydrogenase Nadp Cytoplasmic
Idh
Idh1
Cytosolic Nadp-Isocitrate Dehydrogenase
Idpc
Nadp(+-Specific Icdh
Oxalosuccinate Decarboxylase
Database Links Reactome: R-HSA-2978092
Reactome: R-HSA-389542
Reactome: R-HSA-6798695
Reactome: R-HSA-9033241
Reactome: R-HSA-9818025
Cellular Localisation Cytoplasm
Cytosol
Peroxisome
Alternative Protein Names Isocitrate Dehydrogenase Nadp Cytoplasmic protein
Idh protein
Idh1 protein
Cytosolic Nadp-Isocitrate Dehydrogenase protein
Idpc protein
Nadp(+-Specific Icdh protein
Oxalosuccinate Decarboxylase protein
IDH1 protein
PICD protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJE0009638 Human IDH1 (Isocitrate Dehydrogenase 1, Soluble) Sandwich ELISA Kit (STJE0009638) Human ELISA
STJP016805 Human Malate dehydrogenase 1/MDH1 protein (Recombinant) (His-Tag) (STJP016805) E.coli SDS-PAGE/Enzyme Activity
STJP016726 Human IMP Dehydrogenase 1/IMPDH1 protein (Recombinant) (His-Tag) (STJP016726) E.coli SDS-PAGE
STJA0041783 Anti-Isocitrate Dehydrogenase 1/IDH1 antibody (1-414aa) [AT25H10] (STJA0041783) Mouse Monoclonal Human ELISA/WB/ICC/IF
STJP016629 Human Lactate Dehydrogenase A/LDHA protein (Recombinant) (His-Tag) (STJP016629) E.coli SDS-PAGE/Enzyme Activity

Related Products

!