Biotinylated Human ITGA5&ITGB1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Human Integrin alpha 5 beta 1 (ITGA5&ITGB1) Heterodimer protein (Recombinant) (C-His-Avi) {Biotin} (STJP001546)

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STJP001546
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Short Description :Recombinant-Human Integrin alpha 5 beta 1 (ITGA5&ITGB1) Heterodimer-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Host:HEK293
Note:STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Biotin
Dilution Range:Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Formulation:Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Storage Instruction:The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin:Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol:ITGA5
Gene ID:3678
Uniprot ID:ITA5_HUMAN
Immunogen:DNA sequence encoding Human Integrin alpha 5 beta 1 (ITGA5&ITGB1) Heterodimer including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Immunogen Region:Phe42-Tyr995 (ITGA5) acidic tail & Gln21-Asp728 (ITGB1) basic tail
Post Translational Modifications Proteolytic cleavage by PCSK5 mediates activation of the precursor.
Function Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling. (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Protein Name Integrin Alpha-5
Cd49 Antigen-Like Family Member E
Fibronectin Receptor Subunit Alpha
Integrin Alpha-F
Vla-5
Cd Antigen Cd49e Cleaved Into - Integrin Alpha-5 Heavy Chain - Integrin Alpha-5 Light Chain
Database Links Reactome: R-HSA-1566948
Reactome: R-HSA-1566977
Reactome: R-HSA-202733
Reactome: R-HSA-216083
Reactome: R-HSA-445144
Reactome: R-HSA-8941332
Reactome: R-HSA-9634597
Reactome: R-HSA-9856532
Reactome: R-HSA-9860927
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Focal Adhesion
Alternative Protein Names Integrin Alpha-5 protein
Cd49 Antigen-Like Family Member E protein
Fibronectin Receptor Subunit Alpha protein
Integrin Alpha-F protein
Vla-5 protein
Cd Antigen Cd49e Cleaved Into - Integrin Alpha-5 Heavy Chain - Integrin Alpha-5 Light Chain protein
ITGA5 protein
FNRA protein

Information sourced from Uniprot.org

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