Human ING2 protein (Recombinant) (N-GST & C-His) (STJP007588)

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STJP007588
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ING2-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ING2
Gene ID: 3622
Uniprot ID: ING2_HUMAN
Immunogen Region: Glu204-Glu263
Immunogen: Homo sapiens (Human)
Post Translational Modifications Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71.
Function Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
Protein Name Inhibitor Of Growth Protein 2
Inhibitor Of Growth 1-Like Protein
Ing1lp
P32
P33ing2
Database Links Reactome: R-HSA-3899300
Reactome: R-HSA-6811555
Cellular Localisation Nucleus
Predominantly Nuclear
Localized To Chromatin And Nuclear Matrix
Upon Reduced Ptdins(5)P Levels Seems To Be Released From Chromatin And
At Least Partially
Translocated To The Cytoplasm
Alternative Protein Names Inhibitor Of Growth Protein 2 protein
Inhibitor Of Growth 1-Like Protein protein
Ing1lp protein
P32 protein
P33ing2 protein
ING2 protein
ING1L protein

Information sourced from Uniprot.org

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