| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.43 pg/mL |
| Detection Limit: | 156-100 pg/ml |
| Conjugation: | Biotin |
| Storage Instruction: | Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month. |
| Assay Time: | 4 hours |
| Detection: | Colorimetric |
| Gene Symbol: | IL5 |
| Gene ID: | 3567 |
| Uniprot ID: | IL5_HUMAN |
| Sample Type: | serum, plasma and cell culture supernates |
| Tissue Specificity | Present in peripheral blood mononuclear cells. |
| Post Translational Modifications | |
| Function | Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively. |
| Protein Name | Interleukin-5 Il-5 B-Cell Differentiation Factor I Eosinophil Differentiation Factor T-Cell Replacing Factor Trf |
| Database Links | Reactome: R-HSA-512988 Reactome: R-HSA-5673001 Reactome: R-HSA-912526 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Interleukin-5 ELISA kit Il-5 ELISA kit B-Cell Differentiation Factor I ELISA kit Eosinophil Differentiation Factor ELISA kit T-Cell Replacing Factor ELISA kit Trf ELISA kit IL5 ELISA kit |
| output |
Information sourced from Uniprot.org
