| Tissue Specificity | Present in peripheral blood mononuclear cells. |
| Post Translational Modifications | |
| Function | Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively. |
| Protein Name | Interleukin-5Il-5B-Cell Differentiation Factor IEosinophil Differentiation FactorT-Cell Replacing FactorTrf |
| Database Links | Reactome: R-HSA-512988Reactome: R-HSA-5673001Reactome: R-HSA-912526 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Interleukin-5 ELISA kitIl-5 ELISA kitB-Cell Differentiation Factor I ELISA kitEosinophil Differentiation Factor ELISA kitT-Cell Replacing Factor ELISA kitTrf ELISA kitIL5 ELISA kit |
| output | |
Information sourced from Uniprot.org
