| Function | Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2. |
| Protein Name | Interleukin-1 Family Member 10Il-1f10Family Of Interleukin 1-ThetaFil1 ThetaInterleukin-1 Hy2Il-1hy2Interleukin-1 ThetaIl-1 ThetaInterleukin-38Il-38 |
| Database Links | Reactome: R-HSA-9007892Reactome: R-HSA-9014826 |
| Cellular Localisation | CytoplasmSecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Protein Names | Interleukin-1 Family Member 10 proteinIl-1f10 proteinFamily Of Interleukin 1-Theta proteinFil1 Theta proteinInterleukin-1 Hy2 proteinIl-1hy2 proteinInterleukin-1 Theta proteinIl-1 Theta proteinInterleukin-38 proteinIl-38 proteinIL1F10 proteinFIL1T proteinIL1HY2 proteinIL38 proteinFKSG75 proteinUNQ6119 proteinPRO20041 protein |
Information sourced from Uniprot.org
