• Human IL-3RA/CD123 protein (Recombinant) (C-His) (STJP000897)
  • Human IL-3RA/CD123 protein (Recombinant) (C-His) (STJP000897)
  • Human IL-3RA/CD123 protein (Recombinant) (C-His) (STJP000897)
  • Human IL-3RA/CD123 protein (Recombinant) (C-His) (STJP000897)

Human IL-3RA/CD123 protein (Recombinant) (C-His) (STJP000897)

SKU:
STJP000897

£72.50 - £223.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-3RA/CD123-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized recombinant Human IL3 at 4 Mu g/mL (100 Mu L/well) can bind recombinant Human IL3RA, the EC50 of Human IL3RA is 5.3 Mu g/mL.
Gene Symbol: IL3RA
Gene ID: 3563
Uniprot ID: IL3RA_HUMAN
Immunogen: Recombinant Human IL-3RA/CD123 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Lys20-Arg305) of human IL3RA/CD123 (Accession #NP_002174.1) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Ubiquitinated by RNFT2 in response to IL3. Ubiquitination leads ligand-induced degradation by the proteasome.
Function Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program.
Protein Name Interleukin-3 Receptor Subunit Alpha
Il-3 Receptor Subunit Alpha
Il-3r Subunit Alpha
Il-3r-Alpha
Il-3ra
Cd Antigen Cd123
Database Links Reactome: R-HSA-512988
Reactome: R-HSA-5673001
Reactome: R-HSA-912526
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Interleukin-3 Receptor Subunit Alpha protein
Il-3 Receptor Subunit Alpha protein
Il-3r Subunit Alpha protein
Il-3r-Alpha protein
Il-3ra protein
Cd Antigen Cd123 protein
IL3RA protein
IL3R protein

Information sourced from Uniprot.org

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