Human IL-38/IL-1F10 protein (Recombinant) (No-Tag) (STJP019129)

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STJP019129
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Short Description :Recombinant-Human IL-38/IL-1F10-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in phosphate-Buffered Saline (pH 7.4)
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin:< 1 EU per 1ug of protein (determined by LAL method)
Gene Symbol:IL1F10
Gene ID:84639
Uniprot ID:IL1FA_HUMAN
Accession Number:NP_115945.3
Immunogen:Human
Immunogen Region:1-152aa
Immunogen Sequence:MCSLPMARYY IIKYADQKAL YTRDGQLLVG DPVADNCCAE KICTLPNRGL DRTKVPIFLG IQGGSRCLAC VETEEGPSLQ LEDVNIEELY KGGEEATRFT FFQSSSGSAF RLEAAAWPGW FLCGPAEPQQ PVQLTKESEP SARTKFYFEQ SW
Tissue Specificity Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.
Function Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.
Protein Name Interleukin-1 Family Member 10
Il-1f10
Family Of Interleukin 1-Theta
Fil1 Theta
Interleukin-1 Hy2
Il-1hy2
Interleukin-1 Theta
Il-1 Theta
Interleukin-38
Il-38
Database Links Reactome: R-HSA-9007892
Reactome: R-HSA-9014826
Cellular Localisation Cytoplasm
Secreted
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative Protein Names Interleukin-1 Family Member 10 protein
Il-1f10 protein
Family Of Interleukin 1-Theta protein
Fil1 Theta protein
Interleukin-1 Hy2 protein
Il-1hy2 protein
Interleukin-1 Theta protein
Il-1 Theta protein
Interleukin-38 protein
Il-38 protein
IL1F10 protein
FIL1T protein
IL1HY2 protein
IL38 protein
FKSG75 protein
UNQ6119 protein
PRO20041 protein

Information sourced from Uniprot.org

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