| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g |
| Gene Symbol: | IL31 |
| Gene ID: | 386653 |
| Uniprot ID: | IL31_HUMAN |
| Immunogen Region: | Ser24-Thr164 |
| Immunogen: | Recombinant Human IL-31 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser24-Thr164) of human IL-31 (Accession #NP_001014358.1) fused with a 6×His tag at the N-terminus. |
| Immunogen Sequence: | SHTLPVRLLRPSDDVQKIVE ELQSLSKMLLKDVEEEKGVL VSQNYTLPCLSPDAQPPNNI HSPAIRAYLKTIRQLDNKSV IDEIIEHLDKLIFQDAPETN ISVPTDTHECKRFILTISQQ FSECMDLALKSLTSGAQQAT T |
| Function | Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity. Enhances myeloid progenitor cell survival in vitro. Induces RETNLA and serum amyloid A protein expression in macrophages. |
| Protein Name | Interleukin-31Il-31 |
| Database Links | Reactome: R-HSA-6788467 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-31 proteinIl-31 proteinIL31 protein |
Information sourced from Uniprot.org