Name: Human IL-3 protein (Active Recombinant) (C-His) (STJP001354)
SKU: STJP001354
Availability: InStock

Human IL-3 protein (Active Recombinant) (C-His) (STJP001354)

SKU:

STJP001354

$144.21 - $434.01

Short Description :	Active Recombinant-Human IL-3-C-His protein was developed in hek293 cells using the region Ala20-Phe152. For use in research applications.
Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation:	Unconjugated
Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity:	1.Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED₅₀ for this effect is 1.5-6 ng/mL.\|2.Recombinant Human TPO (50 ng/mL, Cat. RP00174) , IL-3 (15 ng/mL) , IL-6 (15 ng/mL, Cat. RP00201) and IL-11 (15 ng/m
Determination Method:	< 1 EU/Mu g of the protein by LAL method.

Gene Symbol:	IL3
Gene ID:	3562
Uniprot ID:	IL3_HUMAN
Immunogen:	Recombinant Human IL-3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala20-Phe152) of human interleukin-3/IL-3 (Accession #NP_000579.2) fused with a 6×His tag at the C-terminus.
Immunogen Region:	Ala20-Phe152
Immunogen Sequence:	APMTQTTPLKTSWVNCSNMI DEIITHLKQPPLPLLDFNNL NGEDQDILMENNLRRPNLEA FNRAVKSLQNASAIESILKN LLPCLPLATAAPTRHPIHIK DGDWNEFRRKLTFYLKTLEN AQAQQTTLSLAIF

Function	Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Also stimulates mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.
Protein Name	Interleukin-3 Il-3 Hematopoietic Growth Factor Mast Cell Growth Factor Mcgf Multipotential Colony-Stimulating Factor P-Cell-Stimulating Factor
Database Links	Reactome: R-HSA-512988 Reactome: R-HSA-5673001 Reactome: R-HSA-8939247 Reactome: R-HSA-912526
Cellular Localisation	Secreted
Alternative Protein Names	Interleukin-3 protein Il-3 protein Hematopoietic Growth Factor protein Mast Cell Growth Factor protein Mcgf protein Multipotential Colony-Stimulating Factor protein P-Cell-Stimulating Factor protein IL3 protein

Information sourced from Uniprot.org

Model	Name	Host	Application
STJP000974	Human IL-6 protein (Active Recombinant) (C-His) (STJP000974)	HEK293 cells
STJP001119	Human IL-2 protein (Active Recombinant) (C-His) (STJP001119)	HEK293 cells
STJP001250	Human IL-15 protein (Active Recombinant) (C-His) (STJP001250)	E.coli
STJP001264	Human IL-15 protein (Active Recombinant) (C-hFc&His) (STJP001264)	HEK293 cells
STJP012750	Human IL1RL2/IL-36R protein (Recombinant-Active) (C-His) (STJP012750)	Mammalian Cells	ELISA/WB

Human IL-3 protein (Active Recombinant) (C-His) (STJP001354)

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