Human IL-27RA/TCCR protein (Recombinant) (C-hFc) (STJP020181)

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STJP020181-100
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Covered by St John's Laboratory Guarantee

Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: IL27RA
Gene ID: 9466
Uniprot ID: I27RA_HUMAN
Immunogen Region: Gly34-Lys516
Immunogen: Recombinant Human IL-27 Ra/TCCR Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Gly34-Lys516) of Human IL-27 Ra/TCCR fused with a hFc tag at the C-terminal.
Immunogen Sequence: GSAGPLQCYGVGPLGDLNCS WEPLGDLGAPSELHLQSQKY RSNKTQTVAVAAGRSWVAIP REQLTMSDKLLVWGTKAGQP LWPPVFVNLETQMKPNAPRL GPDVDFSEDDPLEATVHWAP PTWPSHKVLICQFHYRRCQE AAWTLLEPELKTIPLTPVEI QDLELATGYKVYGRCRMEKE EDLWGEWSPILSFQTPPSAP KDVWVSGNLCGTPGGEEPLL LWKAPGPCVQVSYKVWFWV
Function Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
Protein Name Interleukin-27 Receptor Subunit Alpha
Il-27 Receptor Subunit Alpha
Il-27r Subunit Alpha
Il-27r-Alpha
Il-27ra
Cytokine Receptor Wsx-1
Cytokine Receptor-Like 1
Type I T-Cell Cytokine Receptor
Tccr
Zcytor1
Database Links Reactome: R-HSA-8984722
Reactome: R-HSA-9020956
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Interleukin-27 Receptor Subunit Alpha protein
Il-27 Receptor Subunit Alpha protein
Il-27r Subunit Alpha protein
Il-27r-Alpha protein
Il-27ra protein
Cytokine Receptor Wsx-1 protein
Cytokine Receptor-Like 1 protein
Type I T-Cell Cytokine Receptor protein
Tccr protein
Zcytor1 protein
IL27RA protein
CRL1 protein
TCCR protein
WSX1 protein
UNQ296 protein
PRO336 protein

Information sourced from Uniprot.org

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