• human IL-25 protein (Recombinant) (C-6His) (STJP001931)
  • human IL-25 protein (Recombinant) (C-6His) (STJP001931)

human IL-25 protein (Recombinant) (C-6His) (STJP001931)

SKU:
STJP001931

£89.50 - £357.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-human IL-25-C-6His protein was developed from hek293 cells and has a target region of C-6His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of 20 mM Tris, 150 mM NaCl, 1 mM EDTA, pH8.0
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its ability to induce CXCL1/GRO alpha secretion in HT-29 human colon adenocarcinoma cells. The ED50 for this effect is 13.32-53.24 ng/mL, corresponding to a specific activity of 1.88×104~7.51×104 units/mg.
Gene Symbol: IL25
Gene ID: 64806
Uniprot ID: IL25_HUMAN
Immunogen Region: Tyr33-Gly177
Immunogen: Recombinant human IL-25 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Tyr33-Gly177) of human IL-25 (Accession #NP_073626.1) fused with a 6×His tag at the C-terminus.
Function Cytokine produced by various cells such as eosinophils, T-helper type 2 (Th2) cells or epithelial cells that plays a role in internal safety of adaptive immune responses by regulating cytokine production. Promotes and augments T-helper type 2 responses locally or systemically. Exerts its activity via its receptor composed of IL17RA and IL17RB for signal transduction. In turn, stimulates the JAK2-STAT5A pathway and promotes the secretion of type-2 associated cytokines including IL4, IL9 and IL13. Induces also the release of IL8, and IL6 from eosinophils through the combined activation of MAPK and NF-kappa-B pathways. Inhibits the differentiation of T-helper (Th17) cells via the production of IL4, IL5 and IL13.
Protein Name Interleukin-25
Il-25
Interleukin-17e
Il-17e
Database Links Reactome: R-HSA-448424
Cellular Localisation Secreted
Alternative Protein Names Interleukin-25 protein
Il-25 protein
Interleukin-17e protein
Il-17e protein
IL25 protein
IL17E protein
UNQ3120 protein
PRO10272 protein

Information sourced from Uniprot.org

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