| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 1.0 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
1.Measured by its binding ability in a functional ELISA. Immobilized Human IL21R at 2 Mu g/mL (100 Mu L/well) can bind Human IL21 with a linear range of 0.078-0.973 Mu g/mL.|2.Measured by its ability to induce Interferon gamma secretion by human natu |
| Gene Symbol: |
IL21 |
| Gene ID: |
59067 |
| Uniprot ID: |
IL21_HUMAN |
| Immunogen Region: |
Gln25-Ser155 |
| Immunogen: |
Recombinant Human IL-21 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln25-Ser155) of human IL-21 (Accession #NP_068575.1) fused with an 6×His tag at the C-terminus. |
| Immunogen Sequence: |
HKSSSQGQDRHMIRMRQLID IVDQLKNYVNDLVPEFLPAP EDVETNCEWSAFSCFQKAQL KSANTGNNERIINVSIKKLK RKPPSTNAGRRQKHRLTCPS CDSYEKKPPKEFLERFKSLL QKMIHQHLSSR |
| Tissue Specificity | Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. |
| Function | Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. |
| Protein Name | Interleukin-21Il-21Za11 |
| Database Links | Reactome: R-HSA-9020958 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-21 proteinIl-21 proteinZa11 proteinIL21 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
