| Host: |
Goat/Goat |
| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
This IL-1R1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Conjugation: |
Unconjugated/Biotin |
| Formulation: |
Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Purification: |
Capture Purification: Antigen Affinity.Detection Purification: Antigen Affinity. |
| Concentration: |
0.5 mg/mL |
| Storage Instruction: |
Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Determination Method: |
Colormetric |
| Gene Symbol: |
IL1R1 |
| Gene ID: |
3554 |
| Uniprot ID: |
IL1R1_HUMAN |
| Immunogen: |
Capture immunogen: Recombinant Human IL-1R1 protien.Detection Immunogen: Recombinant Human IL-1R1 protien. |
| Sample Type: |
Serum, plasma and other biological fluids |
| Post Translational Modifications | A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding). Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1. |
| Function | Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. |
| Protein Name | Interleukin-1 Receptor Type 1Il-1r-1Il-1rt-1Il-1rt1Cd121 Antigen-Like Family Member AInterleukin-1 Receptor AlphaIl-1r-AlphaInterleukin-1 Receptor Type IP80Cd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane FormMil-1r1Mil-1ri - Interleukin-1 Receptor Type 1 - Soluble FormSil-1r1Sil-1ri |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-9020702Reactome: R-HSA-9679191 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell MembraneSecreted |
| Alternative Antibody Pair Names | Interleukin-1 Receptor Type 1 antibody pairIl-1r-1 antibody pairIl-1rt-1 antibody pairIl-1rt1 antibody pairCd121 Antigen-Like Family Member A antibody pairInterleukin-1 Receptor Alpha antibody pairIl-1r-Alpha antibody pairInterleukin-1 Receptor Type I antibody pairP80 antibody pairCd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane Form antibody pairMil-1r1 antibody pairMil-1ri - Interleukin-1 Receptor Type 1 - Soluble Form antibody pairSil-1r1 antibody pairSil-1ri antibody pairIL1R1 antibody pairIL1R antibody pairIL1RA antibody pairIL1RT1 antibody pair |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
