Human IL-17E/IL-25 protein (Recombinant) (His-Tag) (STJP019465)

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STJP019465
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Host: HEK293 Cells
Applications: SDS-PAGE/Bioactivity
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IL-17E/IL-25-His-Tag protein was developed from hek293 cells and has a target region of His-Tag. For use in research applications.
Formulation: Liquid In Phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
Immunoreactivity: Measured by its binding ability in a functional ELISA with Human IL-17 RB
Gene Symbol: IL25
Gene ID: 64806
Uniprot ID: IL25_HUMAN
Immunogen Region: 33-177aa
Accession Number: NP_073626.1
Immunogen: Human
Immunogen Sequence: YSHWPSC CPSKGQDTSE ELLRWSTVPV PPLEPARPNR HPESCRASED GPLNSRAISP WRYELDRDLN RLPQDLYHAR CLCPHCVSLQ TGSHMDPRGN SELLYHNQTV FYRRPCHGEK GTHKGYCLER RLYRVSLACV CVRPRVMG
Tissue Specificity Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.
Function Cytokine produced by various cells such as eosinophils, T-helper type 2 (Th2) cells or epithelial cells that plays a role in internal safety of adaptive immune responses by regulating cytokine production. Promotes and augments T-helper type 2 responses locally or systemically. Exerts its activity via its receptor composed of IL17RA and IL17RB for signal transduction. In turn, stimulates the JAK2-STAT5A pathway and promotes the secretion of type-2 associated cytokines including IL4, IL9 and IL13. Also induces the release of IL8, and IL6 from eosinophils through the combined activation of MAPK and NF-kappa-B pathways. Inhibits the differentiation of T-helper (Th17) cells via the production of IL4, IL5 and IL13.
Protein Name Interleukin-25
Il-25
Interleukin-17e
Il-17e
Database Links Reactome: R-HSA-448424
Cellular Localisation Secreted
Alternative Protein Names Interleukin-25 protein
Il-25 protein
Interleukin-17e protein
Il-17e protein
IL25 protein
IL17E protein
UNQ3120 protein
PRO10272 protein

Information sourced from Uniprot.org

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