| Host: | E.coli |
| Applications: | SDS-PAGE/Denatured |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human IL-12R beta/IL12RB1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol |
| Concentration: | 0.25 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IL12RB1 |
| Gene ID: | 3594 |
| Uniprot ID: | I12R1_HUMAN |
| Immunogen Region: | 1-545aa |
| Accession Number: | NP_005526 |
| Immunogen: | Human |
| Immunogen Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMEPLVTW VVPLLFLFLL SRQGAACRTS ECCFQDPPYP DADSGSASGP RDLRCYRISS DRYECSWQYE GPTAGVSHFL RCCLSSGRCC YFAAGSATRL QFSDQAGVSV LYTVTLWVES WARNQTEKSP EVTLQLYNSV KYEPPLGDIK VSKLAGQLRM EWETPDNQVG AEVQFRHRTP SSPWKLGDCG PQDDDTESCL CPLEMNVA |
| Function | Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Also associates with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. |
| Protein Name | Interleukin-12 Receptor Subunit Beta-1Il-12 Receptor Subunit Beta-1Il-12r Subunit Beta-1Il-12r-Beta-1Il-12rb1Il-12 Receptor Beta ComponentCd Antigen Cd212 |
| Database Links | Reactome: R-HSA-9020591Reactome: R-HSA-9020933 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-12 Receptor Subunit Beta-1 proteinIl-12 Receptor Subunit Beta-1 proteinIl-12r Subunit Beta-1 proteinIl-12r-Beta-1 proteinIl-12rb1 proteinIl-12 Receptor Beta Component proteinCd Antigen Cd212 proteinIL12RB1 proteinIL12R proteinIL12RB protein |
Information sourced from Uniprot.org