Human IK protein (Recombinant) (N-GST) (STJP005286)

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STJP005286
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IK-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: IK
Gene ID: 3550
Uniprot ID: RED_HUMAN
Immunogen Region: Met1-Pro192
Immunogen: Homo sapiens (Human)
Function Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1. (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles.
Protein Name Protein Red
Cytokine Ik
Ik Factor
Protein Rer
Database Links Reactome: R-HSA-72163
Cellular Localisation Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Cytoskeleton
Spindle Pole
Predominantly Present Throughout The Nucleoplasm During Prometaphase
Metaphase And Anaphase
Is Also Detected In Nuclear Foci That Are Not Identical With Cajal Bodies
Starts To Accumulate At Chromosomes During Telophase
And Is Nearly Exclusively Associated With Chromosomes In Newly Divided Cells
Colocalizes With Mad1l1 At Mitotic Spindle Poles During Metaphase And Anaphase
Alternative Protein Names Protein Red protein
Cytokine Ik protein
Ik Factor protein
Protein Rer protein
IK protein
RED protein
RER protein

Information sourced from Uniprot.org