| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | Less than 1 EU per Mu g by the LAL method. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized human IGFBP7 at 2 Mu g/mL (100 Mu L/well) can bind human CD93 with a linear range of 0.17-290.4 ng/mL. |
| Gene Symbol: | IGFBP7 |
| Gene ID: | 3490 |
| Uniprot ID: | IBP7_HUMAN |
| Immunogen Region: | Asp30-Leu282 |
| Immunogen: | Recombinant Human IGFBP-7 Protein Protein is expressed from Expi293 with His tag at the N-terminal.；It contains Asp30-Leu282 |
| Immunogen Sequence: | DTCGPCEPASCPPLPPLGCL LGETRDACGCCPMCARGEGE PCGGGGAGRGYCAPGMECVK SRKRRKGKAGAAAGGPGVSG VCVCKSRYPVCGSDGTTYPS GCQLRAASQRAESRGEKAIT QVSKGTCEQGPSIVTPPKDI WNVTGAQVYLSCEVIGIPTP VLIWNKVKRGHYGVQRTELL PGDRDNLAIQTRGGPEKHEV TGWVLVSPLSKEDAGEYECH ASNSQGQASASAKITVVDA |
| Function | Binds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Acts as a ligand for CD93 to play a role in angiogenesis. |
| Protein Name | Insulin-Like Growth Factor-Binding Protein 7Ibp-7Igf-Binding Protein 7Igfbp-7Igfbp-Rp1Mac25 ProteinPgi2-Stimulating FactorProstacyclin-Stimulating FactorTumor-Derived Adhesion FactorTaf |
| Database Links | Reactome: R-HSA-2559582Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Insulin-Like Growth Factor-Binding Protein 7 proteinIbp-7 proteinIgf-Binding Protein 7 proteinIgfbp-7 proteinIgfbp-Rp1 proteinMac25 Protein proteinPgi2-Stimulating Factor proteinProstacyclin-Stimulating Factor proteinTumor-Derived Adhesion Factor proteinTaf proteinIGFBP7 proteinMAC25 proteinPSF protein |
Information sourced from Uniprot.org