| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized recombinant human IGFBP6 at 1 Mu g/mL (100 Mu L/well) can bind recombinant human IGF1 with a linear range of 30-250 ng/mL. |
| Gene Symbol: |
IGFBP6 |
| Gene ID: |
3489 |
| Uniprot ID: |
IBP6_HUMAN |
| Immunogen Region: |
Met1-Gly240 |
| Immunogen: |
Recombinant Human IGFBP-6 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Gly240) of human IGFBP6/IBP-6 (Accession #NP_002169.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
MTPHRLLPPLLLLLALLLAA SPGGALARCPGCGQGVQAGC PGGCVEEEDGGSPAEGCAEA EGCLRREGQECGVYTPNCAP GLQCHPPKDDEAPLRALLLG RGRCLPARAPAVAEENPKES KPQAGTARPQDVNRRDQQRN PGTSTTPSQPNSAGVQDTEM GPCRRHLDSVLQQLQTEVYR GAQTLYVPNCDHRGFYRKRQ CRSSQGQRRGPCWCVDRMGK SLPGSPDGNGSSSCPTGSS |
| Post Translational Modifications | O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid. |
| Function | IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration. |
| Protein Name | Insulin-Like Growth Factor-Binding Protein 6Ibp-6Igf-Binding Protein 6Igfbp-6 |
| Database Links | Reactome: R-HSA-381426 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Insulin-Like Growth Factor-Binding Protein 6 proteinIbp-6 proteinIgf-Binding Protein 6 proteinIgfbp-6 proteinIGFBP6 proteinIBP6 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
