| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. |
| Protein Name | Interferon Lambda-1Ifn-Lambda-1Cytokine Zcyto21Interleukin-29Il-29 |
| Database Links | Reactome: R-HSA-449836Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Interferon Lambda-1 ELISA kitIfn-Lambda-1 ELISA kitCytokine Zcyto21 ELISA kitInterleukin-29 ELISA kitIl-29 ELISA kitIFNL1 ELISA kitIL29 ELISA kitZCYTO21 ELISA kit |
| output | |
Information sourced from Uniprot.org
