| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | IFNL2 |
| Gene ID: | 282616 |
| Uniprot ID: | IFNL2_HUMAN |
| Immunogen: | Recombinant Human IFN-lambda 2/IL-28A Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val26-Val200) of human IL-28A/IL28A (Accession #NP_742150.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | VPVARLHGALPDARGCHIAQ FKSLSPQELQAFKRAKDALE ESLLLKDCRCHSRLFPRTWD LRQLQVRERPMALEAELALT LKVLEATADTDPALVDVLDQ PLHTLHHILSQFRACIQPQP TAGPRTRGRLHHWLYRLQEA PKKESPGCLEASVTFNLFRL LTRDLNCVASGDLCV |
| Function | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. |
| Protein Name | Interferon Lambda-2 Ifn-Lambda-2 Cytokine Zcyto20 Interleukin-28a Il-28a |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interferon Lambda-2 protein Ifn-Lambda-2 protein Cytokine Zcyto20 protein Interleukin-28a protein Il-28a protein IFNL2 protein IL28A protein ZCYTO20 protein |
Information sourced from Uniprot.org