| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Gene Symbol: | IFNGR2 |
| Gene ID: | 3460 |
| Uniprot ID: | INGR2_HUMAN |
| Immunogen Region: | Ser28-Asp240 |
| Immunogen: | Recombinant Human IFN-gamma R2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser28-Asp240) of human IFN-gamma R2 (Accession #NP_005525.2) fused with and a RaFc tag at the C-terminus. |
| Immunogen Sequence: | SQLPAPQHPKIRLYNAEQVL SWEPVALSNSTRPVVYQVQF KYTDSKWFTADIMSIGVNCT QITATECDFTAASPSAGFPM DFNVTLRLRAELGALHSAWV TMPWFQHYRNVTVGPPENIE VTPGEGSLIIRFSSPFDIAD TSTAFFCYYVHYWEKGGIQQ VKGPFRSNSISLDNLKPSRV YCLQVQAQLLWNKSNIFRVG HLSNISCYETMAD |
| Function | Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Required for signal transduction in contrast to other receptor subunit responsible for ligand binding. |
| Protein Name | Interferon Gamma Receptor 2 Ifn-Gamma Receptor 2 Ifn-Gamma-R2 Interferon Gamma Receptor Accessory Factor 1 Af-1 Interferon Gamma Receptor Beta-Chain Ifn-Gamma-R-Beta Interferon Gamma Transducer 1 |
| Database Links | Reactome: R-HSA-877300 Reactome: R-HSA-877312 Reactome: R-HSA-9679191 Reactome: R-HSA-9732724 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Cytoplasmic Vesicle Membrane Golgi Apparatus Membrane Endoplasmic Reticulum Membrane Cytoplasm Has Low Cell Surface Expression And High Cytoplasmic Expression In T Cells The Bias Towards Cytoplasmic Expression May Be Due To Ligand-Independent Receptor Internalization And Recycling |
| Alternative Protein Names | Interferon Gamma Receptor 2 protein Ifn-Gamma Receptor 2 protein Ifn-Gamma-R2 protein Interferon Gamma Receptor Accessory Factor 1 protein Af-1 protein Interferon Gamma Receptor Beta-Chain protein Ifn-Gamma-R-Beta protein Interferon Gamma Transducer 1 protein IFNGR2 protein IFNGT1 protein |
Information sourced from Uniprot.org