Human IER3 protein (Recombinant) (His-Tag) (STJP018240)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human IER3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% Glycerol, 2mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IER3 |
| Gene ID | 8870 |
| Uniprot ID | IEX1_HUMAN |
| Accession Number | NP_003888.2 |
| Immunogen | Human |
| Immunogen Region | 1-82aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Phosphorylated at Thr-18, Thr-123 and Ser-126 by MAPK1/ERK2 and probably MAPK3/ERK1. Upon phosphorylation by MAPK1/ERK2 and MAPK3/ERK1, acquires the ability to inhibit cell death induced by various stimuli. Glycosylated. |
| Function | May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Also acts as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. |
| Protein Name | Radiation-Inducible Immediate-Early Gene Iex-1Differentiation-Dependent Gene 2 ProteinProtein Dif-2Immediate Early Protein Gly96Immediate Early Response 3 ProteinPacap-Responsive Gene 1 ProteinProtein Prg1 |
| Database Links | Reactome: R-HSA-6811558 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Radiation-Inducible Immediate-Early Gene Iex-1 proteinDifferentiation-Dependent Gene 2 Protein proteinProtein Dif-2 proteinImmediate Early Protein Gly96 proteinImmediate Early Response 3 Protein proteinPacap-Responsive Gene 1 Protein proteinProtein Prg1 proteinIER3 proteinDIF2 proteinIEX1 proteinPRG1 protein |
Information sourced from Uniprot.org