Human ICT1 protein (Recombinant) (His-Tag) (STJP017941)

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STJP017941
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ICT1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 30% Glycerol, 1mM DTT
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: MRPL58
Gene ID: 3396
Uniprot ID: ICT1_HUMAN
Immunogen Region: 30-206aa
Accession Number: NP_001536
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSLHKQKDG TEFKSIYSLD KLYPESQGSD TAWRVPNGAK QADSDIPLDR LTISYCRSSG PGGQNVNKVN SKAEVRFHLA TAEWIAEPVR QKIAITHKNK INRLGELILT SESSRYQFRN LADCLQKIRD MITEASQTPK EPTKEDVKLH RIRIENMNRE RLRQKRIHSA VKTSRRVDMD
Tissue Specificity Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells.
Post Translational Modifications Methylation of glutamine in the GGQ triplet by HEMK1.
Function Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.
Protein Name Large Ribosomal Subunit Protein Ml62
39s Ribosomal Protein L58 - Mitochondrial
Mrp-L58
Digestion Substraction 1
Ds-1
Immature Colon Carcinoma Transcript 1 Protein
Peptidyl-Trna Hydrolase Ict1 - Mitochondrial
Database Links Reactome: R-HSA-5368286
Reactome: R-HSA-5389840
Reactome: R-HSA-5419276
Cellular Localisation Mitochondrion
Alternative Protein Names Large Ribosomal Subunit Protein Ml62 protein
39s Ribosomal Protein L58 - Mitochondrial protein
Mrp-L58 protein
Digestion Substraction 1 protein
Ds-1 protein
Immature Colon Carcinoma Transcript 1 Protein protein
Peptidyl-Trna Hydrolase Ict1 - Mitochondrial protein
MRPL58 protein
DS1 protein
ICT1 protein

Information sourced from Uniprot.org

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