| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human ICOS/CD278-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized human B7-H2/ICOSLG at 1 Mu g/mL (100 Mu L/well) can bind Human ICOS/CD278 with a linear range of 2-14.8 ng/mL. |
| Gene Symbol: |
ICOS |
| Gene ID: |
29851 |
| Uniprot ID: |
ICOS_HUMAN |
| Immunogen: |
Recombinant Human ICOS/CD278 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu21-Phe141) of human ICOS/CD278 (Accession #NP_036224.1) fused with a Fc, 6×His tag at the C-terminus. |
| Post Translational Modifications | N-glycosylated. |
| Function | Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. |
| Protein Name | Inducible T-Cell CostimulatorActivation-Inducible Lymphocyte Immunomediatory MoleculeCd Antigen Cd278 |
| Database Links | Reactome: R-HSA-1257604 Q9Y6W8-1Reactome: R-HSA-2219530 Q9Y6W8-1Reactome: R-HSA-388841 Q9Y6W8-1Reactome: R-HSA-6811558 Q9Y6W8-1 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Protein Names | Inducible T-Cell Costimulator proteinActivation-Inducible Lymphocyte Immunomediatory Molecule proteinCd Antigen Cd278 proteinICOS proteinAILIM protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
