Human ICOS/CD278 protein (Recombinant) (C-hFc&His) (STJP001393)

SKU:
STJP001393
£97.50 - £291.50
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: <0.1 EU/Mu g
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized human B7-H2/ICOSLG at 1 Mu g/mL (100 Mu L/well) can bind Human ICOS/CD278 with a linear range of 2-14.8 ng/mL.
Gene Symbol: ICOS
Gene ID: 29851
Uniprot ID: ICOS_HUMAN
Immunogen: Recombinant Human ICOS/CD278 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu21-Phe141) of human ICOS/CD278 (Accession #NP_036224.1) fused with a Fc, 6×His tag at the C-terminus.
Immunogen Sequence: EINGSANYEMFIFHNGGVQI LCKYPDIVQQFKMQLLKGGQ ILCDLTKTKGSGNTVSIKSL KFCHSQLSNNSVSFFLYNLD HSHANYYFCNLSIFDPPPFK VTLTGGYLHIYESQLCCQLK F
Post Translational Modifications N-glycosylated.
Function Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response. Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Acts also as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection. Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling. In addition, activates PI3K signaling pathways independently of calcium flux. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Protein Name Inducible T-Cell Costimulator
Activation-Inducible Lymphocyte Immunomediatory Molecule
Cd Antigen Cd278
Database Links Reactome: R-HSA-1257604 Q9Y6W8-1
Reactome: R-HSA-2219530 Q9Y6W8-1
Reactome: R-HSA-388841 Q9Y6W8-1
Reactome: R-HSA-6811558 Q9Y6W8-1
Reactome: R-HSA-9725371
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Alternative Protein Names Inducible T-Cell Costimulator protein
Activation-Inducible Lymphocyte Immunomediatory Molecule protein
Cd Antigen Cd278 protein
ICOS protein
AILIM protein

Information sourced from Uniprot.org