Human HTRA1 protein (Recombinant) (N-His) (STJP005786)

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STJP005786
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HTRA1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: HTRA1
Gene ID: 5654
Uniprot ID: HTRA1_HUMAN
Immunogen Region: Gly204-Leu364
Immunogen: Homo sapiens (Human)
Function Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
Protein Name Serine Protease Htra1
High-Temperature Requirement A Serine Peptidase 1
L56
Serine Protease 11
Database Links Reactome: R-HSA-1474228
Cellular Localisation Cell Membrane
Secreted
Cytoplasm
Cytosol
Predominantly Secreted
Also Found Associated With The Plasma Membrane
Alternative Protein Names Serine Protease Htra1 protein
High-Temperature Requirement A Serine Peptidase 1 protein
L56 protein
Serine Protease 11 protein
HTRA1 protein
HTRA protein
PRSS11 protein

Information sourced from Uniprot.org

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