Tissue Specificity | Placenta and skin. Predominantly expressed in mammary gland tissue. |
Post Translational Modifications | |
Function | A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Expected to use NAD(+) as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity (Probable). |
Protein Name | 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type 13 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type I3-Beta-Hsd I3-Beta-Hydroxy-5-Ene Steroid Dehydrogenase3-Beta-Hydroxy-Delta(5-Steroid Dehydrogenase3-Beta-Hydroxysteroid 3-DehydrogenaseDelta-5-3-Ketosteroid IsomeraseDihydrotestosterone OxidoreductaseSteroid Delta-IsomeraseTrophoblast Antigen Fdo161g |
Database Links | Reactome: R-HSA-193048Reactome: R-HSA-193993Reactome: R-HSA-194002 |
Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinMitochondrion Membrane |
Alternative ELISA Names | 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type 1 ELISA kit3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type I ELISA kit3-Beta-Hsd I ELISA kit3-Beta-Hydroxy-5-Ene Steroid Dehydrogenase ELISA kit3-Beta-Hydroxy-Delta(5-Steroid Dehydrogenase ELISA kit3-Beta-Hydroxysteroid 3-Dehydrogenase ELISA kitDelta-5-3-Ketosteroid Isomerase ELISA kitDihydrotestosterone Oxidoreductase ELISA kitSteroid Delta-Isomerase ELISA kitTrophoblast Antigen Fdo161g ELISA kitHSD3B1 ELISA kit3BH ELISA kitHSDB3A ELISA kit |
output | |
Information sourced from Uniprot.org