Human HOMER1 protein (Recombinant) (His-Tag) (STJP016459)

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STJP016459
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HOMER1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 30% Glycerol, and 1mM DTT
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: HOMER1
Gene ID: 9456
Uniprot ID: HOME1_HUMAN
Immunogen Region: 1-354aa
Accession Number: NP_004263
Immunogen: Human
Immunogen Sequence: HMGE QPIFSTRAHV FQIDPNTKKN WVPTSKHAVT VSYFYDSTRN VYRIISLDGS KAIINSTITP NMTFTKTSQK FGQWADSRAN TVYGLGFSSE HHLSKFAEKF QEFKEAARLA KEKSQEKMEL TSTPSQESAG GDLQSPLTPE SINGTDDERT PDVTQNSEPR AEPTQNALPF SHSSAISKHW EAELAT
Function Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
Protein Name Homer Protein Homolog 1
Homer-1
Database Links Reactome: R-HSA-6794361
Cellular Localisation Cytoplasm
Postsynaptic Density
Synapse
Cell Projection
Dendritic Spine
Isoform 1 Inhibits Surface Expression Of Grm5 Causing It To Be Retained In The Endoplasmic Reticulum
Alternative Protein Names Homer Protein Homolog 1 protein
Homer-1 protein
HOMER1 protein
SYN47 protein

Information sourced from Uniprot.org

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