Human HMBS protein (Recombinant) (C-His) (STJP013133)

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STJP013133-100
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Host: Mammalian Cells
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HMBS-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Supplied as a 0.22 Mu m filtered solution in 20mM PB, 150mM NaCl, 5% Trehalose, 5% mannitol, 50% Glycerol, 0.1% Tween 80, pH 7.4.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: HMBS
Gene ID: 3145
Uniprot ID: HEM3_HUMAN
Immunogen Region: Ser2-His361
Immunogen: Homo sapiens (Human)
Function As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact.
Protein Name Porphobilinogen Deaminase
Pbg-D
Hydroxymethylbilane Synthase
Hmbs
Pre-Uroporphyrinogen Synthase
Database Links Reactome: R-HSA-189451
Cellular Localisation Cytoplasm
Cytosol
Alternative Protein Names Porphobilinogen Deaminase protein
Pbg-D protein
Hydroxymethylbilane Synthase protein
Hmbs protein
Pre-Uroporphyrinogen Synthase protein
HMBS protein
PBGD protein
UPS protein

Information sourced from Uniprot.org