Human HHEX protein (Recombinant) (His-Tag) (STJP018344)

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STJP018344
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HHEX-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 40% Glycerol, 1mM DTT
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: HHEX
Gene ID: 3087
Uniprot ID: HHEX_HUMAN
Immunogen Region: 1-270aa
Accession Number: NP_002720
Immunogen: Human
Immunogen Sequence: MQYPHPG PAAGAVGVPL YAPTPLLQPA HPTPFYIEDI LGRGPAAPTP APTLPSPNSS FTSLVSPYRT PVYEPTPIHP AFSHHSAAAL AAAYGPGGFG GPLYPFPRTV NDYTHALLRH DPLGKPLLWS PFLQRPLHKR KGGQVRFSND QTIELEKKFE TQKYLSPPER KRLAKMLQLS ERQVKTWFQN RRAKWRRLKQ ENPQSN
Tissue Specificity Liver and promyelocytic leukemia cell line HL-60.
Function Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. Activator of WNT-mediated transcription in conjunction with CTNNB1. Establishes anterior identity at two levels.acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL. Inhibits EIF4E-mediated mRNA nuclear export. May play a role in hematopoietic differentiation.
Protein Name Hematopoietically-Expressed Homeobox Protein Hhex
Homeobox Protein Hex
Homeobox Protein Prh
Proline-Rich Homeodomain Protein
Database Links Reactome: R-HSA-9925561
Cellular Localisation Nucleus
Nuclear Body
Cytoplasm
Alternative Protein Names Hematopoietically-Expressed Homeobox Protein Hhex protein
Homeobox Protein Hex protein
Homeobox Protein Prh protein
Proline-Rich Homeodomain Protein protein
HHEX protein
HEX protein
PRH protein
PRHX protein

Information sourced from Uniprot.org

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