Human HGFAC protein (Recombinant-Active) (N-His) (STJP012068)

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STJP012068-100
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Host: Mammalian Cells
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human HGFAC-N-His protein was developed from mammalian cells and has a target region of N-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Immunoreactivity: Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK (Dnp)-NH2. The specific activity is >15 pmol/min/µg, as measured under the described conditions.
Gene Symbol: HGFAC
Gene ID: 3083
Uniprot ID: HGFA_HUMAN
Immunogen Region: Gln36-Ser655
Immunogen: Homo sapiens (Human)
Post Translational Modifications The active form of HGFAC presents in the serum is derived from the COOH-terminal region of the precursor by the cleavage of bonds between Arg-372 and Val-373 and Arg-407 and Ile-408.
Function Serine protease that hydrolyzes the inactive zymogen hepatocyte growth factor (HGFsc) to an activated disulfide-linked heterodimer, then initiating hepatocyte growth factor receptor signaling pathway.
Protein Name Hepatocyte Growth Factor Activator Serine Protease
Hgf Activator
Hgfa
Hgfa Serine Protease
Serine Protease Hgfac Cleaved Into - Hepatocyte Growth Factor Activator Short Chain - Hepatocyte Growth Factor Activator Long Chain
Database Links Reactome: R-HSA-6806942
Cellular Localisation Secreted
Exists As An Inactive Zymogen In Plasma
Exists As An Active Heterodimeric Form In Serum
Alternative Protein Names Hepatocyte Growth Factor Activator Serine Protease protein
Hgf Activator protein
Hgfa protein
Hgfa Serine Protease protein
Serine Protease Hgfac Cleaved Into - Hepatocyte Growth Factor Activator Short Chain - Hepatocyte Growth Factor Activator Long Chain protein
HGFAC protein

Information sourced from Uniprot.org