Human HCVADR/CXADR protein (Recombinant) (C-His) (STJP001071)

General Information
Product Properties
Target Information
Additional Info
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Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human HCVADR/CXADR-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:

Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.

Gene Symbol:	CXADR
Gene ID:	1525
Uniprot ID:	CXAR_HUMAN
Immunogen:	Recombinant Human HCVADR/CXADR Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Leu20-Gly237) of human CXADR/CAR (Accession #NP_001329.1) fused with a 6×His tag at the C-terminus.

Tissue Specificity	Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.
Post Translational Modifications	N-glycosylated. Palmitoylated on Cys-259 and/or Cys-260.required for proper localization to the plasma membrane.
Function	Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. (Microbial infection) Acts as a receptor for adenovirus type C. (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6.
Protein Name	Coxsackievirus And Adenovirus Receptor Car Hcar Cvb3-Binding Protein Coxsackievirus B-Adenovirus Receptor Hcvadr
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-202733
Cellular Localisation	Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Basolateral Cell Membrane Cell Junction Tight Junction Adherens Junction In Epithelial Cells Localizes To The Apical Junction Complex Composed Of Tight And Adherens Junctions In Airway Epithelial Cells Localized To Basolateral Membrane But Not To Apical Surface Isoform 3: Secreted Isoform 4: Secreted Isoform 5: Secreted
Alternative Protein Names	Coxsackievirus And Adenovirus Receptor protein Car protein Hcar protein Cvb3-Binding Protein protein Coxsackievirus B-Adenovirus Receptor protein Hcvadr protein CXADR protein CAR protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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