| Tissue Specificity | Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection. |
| Function | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. |
| Protein Name | Ragulator Complex Protein Lamtor5Hepatitis B Virus X-Interacting ProteinHbv X-Interacting ProteinHbx-Interacting ProteinLate Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 5 |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-165159Reactome: R-HSA-166208Reactome: R-HSA-380972Reactome: R-HSA-5628897Reactome: R-HSA-8943724Reactome: R-HSA-9639288 |
| Cellular Localisation | LysosomeCytoplasmCytosol |
| Alternative Protein Names | Ragulator Complex Protein Lamtor5 proteinHepatitis B Virus X-Interacting Protein proteinHbv X-Interacting Protein proteinHbx-Interacting Protein proteinLate Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 5 proteinLAMTOR5 proteinHBXIP proteinXIP protein |
Information sourced from Uniprot.org
