| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.116ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description: | This GRIA3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | GRIA3 |
| Gene ID: | 2892 |
| Uniprot ID: | GRIA3_HUMAN |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission by inducing long-term potentiation. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of calcium. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
| Protein Name | Glutamate Receptor 3 Glur-3 Ampa-Selective Glutamate Receptor 3 Glur-C Glur-K3 Glutamate Receptor Ionotropic - Ampa 3 |
| Database Links | Reactome: R-HSA-399710 Reactome: R-HSA-399719 Reactome: R-HSA-416993 Reactome: R-HSA-438066 Reactome: R-HSA-8849932 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Postsynaptic Cell Membrane Postsynaptic Density Membrane |
| Alternative ELISA Names | Glutamate Receptor 3 ELISA kit Glur-3 ELISA kit Ampa-Selective Glutamate Receptor 3 ELISA kit Glur-C ELISA kit Glur-K3 ELISA kit Glutamate Receptor Ionotropic - Ampa 3 ELISA kit GRIA3 ELISA kit GluA3 ELISA kit GLUR3 ELISA kit GLURC ELISA kit |
| output |
Information sourced from Uniprot.org
