SDS-PAGE gel of recombinant human Granzyme B protein 3μg under reducing conditions Coomassie stain

Human Granzyme B protein (Recombinant) (His-Tag) (STJP019065)

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STJP019065
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Short Description :Recombinant-Human Granzyme B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Denatured
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:GZMB
Gene ID:3002
Uniprot ID:GRAB_HUMAN
Accession Number:NP_004122
Immunogen:Human
Immunogen Region:21-247aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MIIGGHEAKP HSRPYMAYLM IWDQKSLKRC GGFLIQDDFV LTAAHCWGSS INVTLGAHNI KEQEPTQQFI PVKRPIPHPA YNPKNFSNDI MLLQLERKAK RTRAVQPLRL PSNKAQVKPG QTCSVAGWGQ TAPLGKHSHT LQEVKMTVQE DRKCESDLRH YYDSTIELCV GDPEIKKTSF KGDSGGPLVC NKVAQGIVSY GRNNGMPP
Function Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair.
Protein Name Granzyme B
C11
Ctla-1
Cathepsin G-Like 1
Ctsgl1
Cytotoxic T-Lymphocyte Proteinase 2
Lymphocyte Protease
Fragmentin-2
Granzyme-2
Human Lymphocyte Protein
Hlp
Sect
T-Cell Serine Protease 1-3e
Database Links Reactome: R-HSA-2197563
Reactome: R-HSA-5620971
Reactome: R-HSA-75108
Reactome: R-HSA-9725371
Cellular Localisation Secreted
Cytolytic Granule
Delivered Into The Target Cell By Perforin
Alternative Protein Names Granzyme B protein
C11 protein
Ctla-1 protein
Cathepsin G-Like 1 protein
Ctsgl1 protein
Cytotoxic T-Lymphocyte Proteinase 2 protein
Lymphocyte Protease protein
Fragmentin-2 protein
Granzyme-2 protein
Human Lymphocyte Protein protein
Hlp protein
Sect protein
T-Cell Serine Protease 1-3e protein
GZMB protein
CGL1 protein
CSPB protein
CTLA1 protein
GRB protein

Information sourced from Uniprot.org

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