| Tissue Specificity | |
| Post Translational Modifications | The serines in positions 32 and 33 are absent in 80% of the sequenced protein. |
| Function | The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Has cholesterol transfer activity. |
| Protein Name | Ganglioside Gm2 ActivatorCerebroside Sulfate Activator ProteinGm2-ApSphingolipid Activator Protein 3Sap-3 Cleaved Into - Ganglioside Gm2 Activator Isoform Short |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-9840310 |
| Cellular Localisation | Lysosome |
| Alternative ELISA Names | Ganglioside Gm2 Activator ELISA kitCerebroside Sulfate Activator Protein ELISA kitGm2-Ap ELISA kitSphingolipid Activator Protein 3 ELISA kitSap-3 Cleaved Into - Ganglioside Gm2 Activator Isoform Short ELISA kitGM2A ELISA kit |
| output | |
Information sourced from Uniprot.org
