| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.061ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description: | This GM2A Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | GM2A |
| Gene ID: | 2760 |
| Uniprot ID: | SAP3_HUMAN |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | The serines in positions 32 and 33 are absent in 80% of the sequenced protein. |
| Function | The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Has cholesterol transfer activity. |
| Protein Name | Ganglioside Gm2 Activator Cerebroside Sulfate Activator Protein Gm2-Ap Sphingolipid Activator Protein 3 Sap-3 Cleaved Into - Ganglioside Gm2 Activator Isoform Short |
| Database Links | Reactome: R-HSA-6798695 Reactome: R-HSA-9840310 |
| Cellular Localisation | Lysosome |
| Alternative ELISA Names | Ganglioside Gm2 Activator ELISA kit Cerebroside Sulfate Activator Protein ELISA kit Gm2-Ap ELISA kit Sphingolipid Activator Protein 3 ELISA kit Sap-3 Cleaved Into - Ganglioside Gm2 Activator Isoform Short ELISA kit GM2A ELISA kit |
| output |
Information sourced from Uniprot.org
