• Biotinylated Human GITR Ligand Trimer on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human GITR Ligand Trimer is greater than 95% as determined by SEC-HPLC.
  • Immobilized Human GITR, His Tag at 1 Mu g/ml (100 Mu l/Well). Dose response curve for Biotinylated Human GITR Ligand Trimer, His Tag with the EC50 of 0. 2 Mu g/ml determined by ELISA.

Human GITR Ligand/TNFSF18 Trimer protein (Recombinant) (N-His-Flag) {Biotin} (STJP001553)

SKU:
STJP001553

£618.50 - £1,909.50
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human GITR Ligand/TNFSF18 Trimer-N-His-Flag protein was developed from hek293 and has a target region of N-His-Flag. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: TNFSF18
Gene ID: 8995
Uniprot ID: TNF18_HUMAN
Immunogen Region: Gln50-Ser177
Immunogen: DNA sequence encoding Human GITR Ligand/TNFSF18 Trimer (Primary Amine Labeling) including a N-His-Flag tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Function Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation.
Protein Name Tumor Necrosis Factor Ligand Superfamily Member 18
Activation-Inducible Tnf-Related Ligand
Aitrl
Glucocorticoid-Induced Tnf-Related Ligand
Hgitrl
Database Links Reactome: R-HSA-5669034
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names Tumor Necrosis Factor Ligand Superfamily Member 18 protein
Activation-Inducible Tnf-Related Ligand protein
Aitrl protein
Glucocorticoid-Induced Tnf-Related Ligand protein
Hgitrl protein
TNFSF18 protein
AITRL protein
GITRL protein
TL6 protein
UNQ149 protein
PRO175 protein

Information sourced from Uniprot.org

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