Human GILT/IFI30 protein (Recombinant) (His-Tag) (STJP017861)

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STJP017861
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GILT/IFI30-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% Glycerol, 1mM DTT
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: IFI30
Gene ID: 10437
Uniprot ID: GILT_HUMAN
Immunogen Region: 58-232aa
Accession Number: NP_006323
Immunogen: Human
Immunogen Sequence: NAPLVN VTLYYEALCG GCRAFLIREL FPTWLLVMEI LNVTLVPYGN AQEQNVSGRW EFKCQHGEEE CKFNKVEACV LDELDMELAF LTIVCMEEFE DMERSLPLCL QLYAPGLSPD TIMECAMGDR GMQLMHANAQ RTDALQPPHE YVPWVTVNGK PLEDQTQLLT LVCQLYQGK
Post Translational Modifications N-glycosylated. Sugar chains contain mannose-6-phosphate. Synthesized as a 35 kDa precursor which is then processed into the mature 30 kDa form via cleavage of N-terminal and C-terminal propeptides. Processing of the precursor is mediated by multiple lysosomal proteases.
Function Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Also facilitates MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation.
Protein Name Gamma-Interferon-Inducible Lysosomal Thiol Reductase
Gamma-Interferon-Inducible Protein Ip-30
Legumaturain
Database Links Reactome: R-HSA-2132295
Reactome: R-HSA-877300
Cellular Localisation Secreted
Lysosome
Alternative Protein Names Gamma-Interferon-Inducible Lysosomal Thiol Reductase protein
Gamma-Interferon-Inducible Protein Ip-30 protein
Legumaturain protein
IFI30 protein
GILT protein
IP30 protein

Information sourced from Uniprot.org

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