Human GID8 protein (Recombinant) (His-Tag) (STJP019154)

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STJP019154
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GID8-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol, 1mM DTT
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: GID8
Gene ID: 54994
Uniprot ID: GID8_HUMAN
Immunogen Region: 1-228aa
Accession Number: NP_060366
Immunogen: Human
Immunogen Sequence: MSYAEKP DEITKDEWME KLNNLHVQRA DMNRLIMNYL VTEGFKEAAE KFRMESGIEP SVDLETLDER IKIREMILKG QIQEAIALIN SLHPELLDTN RYLYFHLQQQ HLIELIRQRE TEAALEFAQT QLAEQGEESR ECLTEMERTL ALLAFDSPEE SPFGDLLHTM QRQKVWSEVN QAVLDYENRE STPKLAKLLK LLLWAQ
Tissue Specificity Up-regulated in colorectal cancer tissues (at protein level).
Post Translational Modifications Polyubiquitinated through 'Lys-48'-polyubiquitin chains, leading to proteasomal degradation in the absence of Wnt stimulation.
Function Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation.
Protein Name Glucose-Induced Degradation Protein 8 Homolog
Two Hybrid-Associated Protein 1 With Ranbpm
Twa1
Database Links Reactome: R-HSA-9861718
Cellular Localisation Cytoplasm
Nucleus
Localizes In The Cytoplasm In The Absence Of Wnt Stimulation And In The Nucleus In The Presence Of Wnt Stimulation
Alternative Protein Names Glucose-Induced Degradation Protein 8 Homolog protein
Two Hybrid-Associated Protein 1 With Ranbpm protein
Twa1 protein
GID8 protein
C20orf11 protein
TWA1 protein

Information sourced from Uniprot.org

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