Human GHRL protein (Recombinant) (N-His) (STJP006138)

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STJP006138
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GHRL-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: GHRL
Gene ID: 51738
Uniprot ID: GHRL_HUMAN
Immunogen Region: Ser25-Lys117
Immunogen: Homo sapiens (Human)
Post Translational Modifications O-octanoylated by GOAT/MBOAT4. O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid. Also O-acetylated and O-butyrylated on Ser-26 to minor levels. Amidation of Leu-98 is essential for obestatin activity.
Function Ghrelin-27: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Ghrelin-28: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin: May be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
Protein Name Appetite-Regulating Hormone
Growth Hormone Secretagogue
Growth Hormone-Releasing Peptide
Motilin-Related Peptide
Protein M46 Cleaved Into - Ghrelin-27 - Ghrelin-28
Ghrelin - Obestatin
Database Links Reactome: R-HSA-375276 Q9UBU3-1
Reactome: R-HSA-416476 Q9UBU3-1
Reactome: R-HSA-422085
Cellular Localisation Secreted
Alternative Protein Names Appetite-Regulating Hormone protein
Growth Hormone Secretagogue protein
Growth Hormone-Releasing Peptide protein
Motilin-Related Peptide protein
Protein M46 Cleaved Into - Ghrelin-27 - Ghrelin-28 protein
Ghrelin - Obestatin protein
GHRL protein
MTLRP protein
UNQ524 protein
PRO1066 protein

Information sourced from Uniprot.org

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