| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human GHRL/MTLRP-C-RaFC protein was developed from hek293 cells and has a target region of C-RaFC. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GHRL |
| Gene ID: |
51738 |
| Uniprot ID: |
GHRL_HUMAN |
| Immunogen Region: |
Gly24-Lys117 |
| Immunogen: |
Recombinant Human GHRL/MTLRP Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Lys117) of human GHRL/MTLRP (Accession #NP_001128413.1) fused with RaFc tag at the C-terminus. |
| Post Translational Modifications | O-octanoylated by GOAT/MBOAT4. O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid. Also O-acetylated and O-butyrylated on Ser-26 to minor levels. Amidation of Leu-98 is essential for obestatin activity. |
| Function | Ghrelin-27: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Ghrelin-28: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin: May be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility. |
| Protein Name | Appetite-Regulating HormoneGrowth Hormone SecretagogueGrowth Hormone-Releasing PeptideMotilin-Related PeptideProtein M46 Cleaved Into - Ghrelin-27 - Ghrelin-28Ghrelin - Obestatin |
| Database Links | Reactome: R-HSA-375276 Q9UBU3-1Reactome: R-HSA-416476 Q9UBU3-1Reactome: R-HSA-422085 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Appetite-Regulating Hormone proteinGrowth Hormone Secretagogue proteinGrowth Hormone-Releasing Peptide proteinMotilin-Related Peptide proteinProtein M46 Cleaved Into - Ghrelin-27 - Ghrelin-28 proteinGhrelin - Obestatin proteinGHRL proteinMTLRP proteinUNQ524 proteinPRO1066 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
