Human PTPRC/CD45/CD45RA protein (Recombinant) (C-raFc) (STJP001525)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human PTPRC/CD45/CD45RA Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln26-Lys482) of human PTPRC/CD45/CD45RA (Accession #AAD15273.2) fused with a raFc tag at the C-terminus.
General Information
| Short Description | Recombinant-Human PTPRC/CD45/CD45RA-C-raFc protein was developed in hek293 cells using the region Gln26-Lys482. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | PTPRC |
| Gene ID | 5788 |
| Uniprot ID | PTPRC_HUMAN |
| Immunogen | Recombinant Human PTPRC/CD45/CD45RA Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln26-Lys482) of human PTPRC/CD45/CD45RA (Accession #AAD15273.2) fused with a raFc tag at the C-terminus. |
| Immunogen Region | Gln26-Lys482 |
| Immunogen Sequence | QSPTPSPTGLTTAKMPSVPL SSDPLPTHTTAFSPASTFER ENDFSETTTSLSPDNTSTQV SPDSLDNASAFNTTDAYLNA SETTTLSPSGSAVISTTTIA TTPSKPTCDEKYANITVDYL YNKETKLFTAKLNVNENVEC GNNTCTNNEVHNLTECKNAS VSISHNSCTAPDKTLILDVP PGVEKFQLHDCTQVEKADTT ICLKWKNIETFTCDTQNITY RFQCGNMIFDNKEIKLENL |
Additional Info
| Post Translational Modifications | Heavily N- and O-glycosylated. |
| Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. Interacts with CLEC10A at antigen presenting cell-T cell contact.CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity. (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase CLeukocyte Common AntigenL-CaT200Cd Antigen Cd45 |
| Database Links | Reactome: R-HSA-202427Reactome: R-HSA-416700Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftSynapseColocalized With Dpp4 In Membrane Rafts |
| Alternative Protein Names | Receptor-Type Tyrosine-Protein Phosphatase C proteinLeukocyte Common Antigen proteinL-Ca proteinT200 proteinCd Antigen Cd45 proteinPTPRC proteinCD45 protein |
Information sourced from Uniprot.org