Human GFRA2 protein (Recombinant) (N-His) (STJP007293)

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STJP007293
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GFRA2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: GFRA2
Gene ID: 2675
Uniprot ID: GFRA2_HUMAN
Immunogen Region: Asp226-Ser444
Immunogen: Homo sapiens (Human)
Function Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons. NRTN-binding leads to autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Isoform 2: Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.
Protein Name Gdnf Family Receptor Alpha-2
Gdnf Receptor Alpha-2
Gdnfr-Alpha-2
Gfr-Alpha-2
Gdnf Receptor Beta
Gdnfr-Beta
Neurturin Receptor Alpha
Nrtnr-Alpha
Ntnr-Alpha
Ret Ligand 2
Tgf-Beta-Related Neurotrophic Factor Receptor 2
Database Links Reactome: R-HSA-419037
Reactome: R-HSA-5673001
Reactome: R-HSA-8853659
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Alternative Protein Names Gdnf Family Receptor Alpha-2 protein
Gdnf Receptor Alpha-2 protein
Gdnfr-Alpha-2 protein
Gfr-Alpha-2 protein
Gdnf Receptor Beta protein
Gdnfr-Beta protein
Neurturin Receptor Alpha protein
Nrtnr-Alpha protein
Ntnr-Alpha protein
Ret Ligand 2 protein
Tgf-Beta-Related Neurotrophic Factor Receptor 2 protein
GFRA2 protein
GDNFRB protein
RETL2 protein
TRNR2 protein

Information sourced from Uniprot.org

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